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    Shenzhen OK Biotech Technology Co., Ltd. (SZOB)

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> Tsev > Khoom > Pharmaceutical > API > Cov ntsiab lus

Testosterone (58-22-0)

Testosterone belongs rau ib chav kawm ntawm cov tshuaj hormones hu ua androgens; hauv-qhov tseeb qhov no yog qhov tshuaj hormone thawj androgenic. Ib txoj kev loj heev hauv nws txoj cai, testosterone yog lub luag haujlwm loj heev rau kev sim tshuaj thiab prostate txoj kev loj hlob, as Well as txoj kev loj hlob ntawm cov leeg nqaij, pob txha ceev thiab lub zog.ZOB Muab Siab Purity Testosterone Nyoos Hmoov thiab Dawb Reship Txoj cai.Qhov zoo yog kiag li Guaranteed , Qhov Zoo Yog Peb Lub Hlis. Ua Siab Rau Koj Daim Ntawv Xaj. ..


1. Testosterone raw hmoov yog dab tsi?  

Testosterone belongs rau ib chav kawm ntawm cov tshuaj hormones hu ua androgens; hauv-qhov tseeb qhov no yog qhov tshuaj hormone thawj androgenic. Txoj kev loj heev hauv nws tus kheej txoj cai, testosterone yog lub luag haujlwm loj heev rau kev kuaj qog thiab prostate, nrog rau kev txhim kho ntawm cov leeg nqaij, pob txha ceev thiab lub zog. Tshaj li cov dej num yooj yim, testosterone yog ib qho tseem ceeb heev rau peb txoj kev noj qab haus huv thiab kev nyab xeeb; Qib qis ntawm testosterone tsis tuaj yeem tsuas cuam tshuam rau cov leeg nqaij thiab pob txha tab sis tuaj yeem cuam tshuam rau peb lub xeev siab.

 

Thaum uas yog ib tug tub ntxhais kawm ntawv uas muaj cov tshuaj hormone hauv androgenic steroidal hormones, testosterone kuj yog ib qho anabolic heev. Raws li ob qho tib si androgenic thiab anabolic, zoo li txhua yam tshuaj steroidal hormones testosterone yog muab los ntawm cov cholesterol thiab feem ntau tswj raws kev tsim cov tshuaj los ntawm luteinizing hormones (LH) thiab follicle stimulating hormones (FSH). Kev tswj hwm los ntawm LH thiab FSH, txhawm rau cov tshuaj hormones no tawm hauv lub caj pas pituitary yuav tsum xub ua kom muaj lub hom phiaj no; ib zaug tiav thiab LH thiab FSH raug tso tawm, kev sim stimulation yog ua tiav li uas ua rau qhov kev sim ntawm testosterone. Raws li koj tau yooj yim pom, qhov tseem ceeb tshaj li cov noob qes hauv cov testosterone, cov pituitary caj pas tseem ceeb sib luag; tsis muaj pituitary muaj nuj nqi natural testosterone ntau lawm tsis tuaj yeem tshwm sim.


Pawg Organon nyob rau hauv Netherlands yog thawj tus tawm cov tshuaj hormone, txheeb tau lub Tsib Hlis 1935 "On Crystalline Txiv neej Hormone los ntawm Qoob loo (Testosterone)". Lawv hu ua tus testosterone hormone, los ntawm stems ntawm testicle thiab sterol, thiab lub SRI ntawm ketone. Tus qauv tau ua haujlwm los ntawm Schering Adolf Butenandt, ntawm Chemisches Institut ntawm Technical University nyob Gdansk


Cov tshuaj synthesis ntawm testosterone los ntawm cholesterol tau tiav thaum lub Yim Hli xyoo ntawd los ntawm Butenandt thiab Hanisch. Tsuas yog ib lub lim tiam tom qab, Cub pawg hauv Zurich, Leopold Ruzicka (1887-1976) thiab A. Wettstein, tau luam tawm lawv cov synthesis ntawm testosterone.These ib nrab ntawm cov testosterone ntawm tus cholesterol tau nyiaj tau ob lub Butenandt thiab Ruzicka qhov kev sib koom tes 1939 Nobel Prize rau Chemistry.Testosterone tau pom tias yog 17β-hydroxyandrost-4-en-3-ib (C19H28O2), muaj cov cawv cuaj caum nrog ib pab pawg hydroxyl ntawm 17th cov atom. Qhov no kuj ua rau nws pom tseeb tias qhov kev hloov ntxiv ntawm kev sim synthesized testosterone yuav tau ua, piv txwv li, esterification thiab alkylation.


Testosterone tau pom nyob hauv feem ntau vertebrates. Testosterone thiab tus ciaj caws nuclear androgen receptor thawj zaug tshwm hauv gnathostomes (lub vertebrates jawed). Agnathans (lub voj vertebrates tsis zoo) xws li lampreys tsis tsim testosterone, tiam sis tsuas yog siv thiab androstenedione ua ib tug txiv neej pw hormone. Ntses ua tau ib daim ntawv me me hu ua 11-ketotestosterone.Thaum cov kab mob hauv cov kab no yog ecdysone.Qhov muaj cov kab mob hauv cov kab mob uas nyob hauv ntau hom tsiaj hais tias cov tshuaj hormones pw muaj keeb kwm yav dhau evolutionary.





2. Testosterone nyoos hmoov ua haujlwm li cas?

Cov teebmeem ntawm testosterone rau tib neeg thiab lwm cov vertebrates tshwm sim los ntawm kev muaj ntau hom mechanisms: los ntawm kev ua rau ntawm androgen reseptor (ncaj qha los yog ua DHT), thiab los ntawm kev hloov mus estradiol thiab ua kom muaj qee cov tshuaj receptors.Androgens xws li testosterone kuj tau pom khi rau thiab qhib cov membrane androgen receptors.


Dawb testosterone (T) yog thauj mus rau hauv cytoplasm ntawm lub hlwb cov phiaj nqaij, qhov twg nws tuaj yeem khi rau lub androgen reseptor, los yog txo tau mus rau 5α-dihydrotestosterone (DHT) los ntawm cytoplasmic enzyme 5α-reductase. DHT khi rau tib lub cev thiab cov tshuaj recruit tau ntau tshaj li testosterone, kom nws cov androgenic potency yog kwv yees li 5 zaug ntawm T. [149] Tus T-receptor los yog DHT-reseptor complex yauv ua rau muaj kev hloov pauv uas tso cai rau nws txav mus rau hauv lub xov tooj ntawm tes thiab khi ncaj qha mus rau hom kev zais nucleotide ntawm chromosomal DNA. Cov chaw ntawm kev tiv thaiv yog hu ua hormone response elements (HREs), thiab cuam tshuam kev ua haujlwm ntawm qee cov noob, ua rau muaj cov teebmeem androgen.


Androgen cov phaj nyaj muaj tshwm sim hauv ntau lub cev nqaij daim tawv, thiab cov poj niam thiab cov poj niam sib thooj li sib luag. Muaj ntau yam sib txawv ntawm testosterone prenatally, thaum puberty, thiab thoob plaws hauv lub neej account rau ib feem ntawm kev sib txawv ntawm cov txivneej thiab cov pojniam.


Cov pob txha thiab lub hlwb yog ob yam tseem ceeb hauv cov tib neeg uas yog thawj cov nyhuv ntawm testosterone yog los ntawm kev aromatization rau estradiol. Nyob rau hauv cov pob txha, estradiol accelerates ossification ntawm pob txha mos ua pob txha, ua rau kev kaw ntawm cov epiphyses thiab xaus ntawm txoj kev loj hlob. Nyob rau hauv lub hauv paus paj hlwb, testosterone yog aromatized rau estradiol. Estradiol ntau dua li testosterone ua hauj lwm raws li cov lus ceeb toom tseem ceeb tshaj plaws rau cov hypothalamus (tshwj xeeb tshaj yog cuam tshuam rau LH secretion). Nyob rau hauv ntau hom tsiaj, plab hnyuv laus los yog plab hnyuv "ploj" ntawm qhov chaw ntawm kev sib deev dimorphic ntawm lub hlwb los ntawm estradiol muab tau los ntawm testosterone cov kev pab cuam tom qab txiv neej tus cwj pwm.





3. Yuav siv cov tshuaj hu ua Testosterone raw li cas?

Testosterone yog siv los ua ib yam tshuaj rau kev kho cov txiv neej uas tsis tshuav tsawg lossis tsis muaj natural testosterone, qee hom kev mob qog nqaij hlav cancer mis, thiab poj niam txiv neej nyob rau hauv cov poj niam txiv neej. Qhov no yog hu ua hormone replacement therapy (HRT) los yog kev hloov kho tshuaj (TRT), uas tswj cov kev kuaj ntshav serum testosterone qib hauv ntau yam. Kev txiav txim ntawm testosterone ntau nrog lub hnub nyoog tau coj mus rau kev txaus siab nyob rau hauv androgen hloov kho.Nws yog tsis meej yog hais tias kev siv testosterone rau tsawg theem vim laus yog lig los yog teeb meem.

 

Testosterone yog thawj tus poj niam txiv neej pw thiab ib qho anabolic steroid. Cov txiv neej, testosterone plays lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm cov txiv neej deev xws li cov testis thiab prostate, thiab kev txhawb qib lwm yam kev sib deev xws li cov nqaij ntshiv thiab pob txha, thiab kev loj hlob ntawm lub cev plaub hau.Thaum ntawd, testosterone muab kev koom tes hauv kev noj qab haus huv thiab kev thaj yeeb, thiab kev tiv thaiv kev txha. Cov qib theem tsis txaus ntawm cov txiv neej tuaj yeem ua rau muaj kev txawv txav xws li kev thev plaub thiab pob txha.


Testosterone kuj tseem yog siv tshuaj los kho cov txiv neej hypogonadism thiab qee yam hom mob cancer ntawm lub mis.Vim li testosterone qib qis thaum txiv neej hnub nyoog, synthetic testosterone qee zaum tau qhia rau cov txiv neej los tiv thaiv qhov tsis muaj peev xwm no.


Testosterone yog ib qho tshuaj steroid ntawm chav kawm androstane uas muaj cov kab keto thiab cov hydroxyl pawg ntawm peb thiab kaumxeeb txoj haujlwm. Nws yog biosynthesized nyob rau hauv ob peb kauj ruam los ntawm cov cholesterol thiab hloov dua siab tshiab nyob rau hauv lub siab kom tsis muaj zog metabolites. Nws exerts nws cov kev txiav txim los ntawm kev ruaj ntseg rau thiab ua kom cov tub ntxhais thiab cov neeg tuaj yeem txais cov tubrog.


Nyob rau hauv tib neeg thiab lwm cov vertebrates, testosterone yog secreted feem ntau ntawm cov noob qes ntawm cov txiv neej thiab, tsawg dua, tus zes qe menyuam ntawm cov pojniam. Qhov nruab nrab, cov neeg laus cov txiv neej, theem ntawm testosterone muaj li 7-8 zaus zoo li hauv cov poj niam laus. Raws li kev siv metabolic testosterone hauv cov txiv neej muaj ntau dua, txhua txhua hnub yog 20 feem pua ​​ntau dua rau cov txiv neej. Cov pojniam kuj tseem ceeb tshaj rau cov tshuaj hormone.





4. Muab tshuaj rau cov hmoov nplej

Testosterone yog ib tug txiv neej pw ua ke uas tseem ceeb heev rau kev sib deev thiab kev loj hlob. Lub National Institutes of Health regards testosterone yog qhov tseem ceeb tshaj plaws txiv neej hormone. Cov poj niam kuj tsim testosterone, tab sis nyob rau theem qis dua txiv neej.


Testosterone belongs rau ib chav kawm ntawm cov txiv neej hormones hu ua androgens, uas qee zaus hu ua steroids lossis anabolic steroids. Nyob rau hauv cov txiv neej, testosterone yog ua los ntawm cov kab mob, nrog ib qho me me hauv cov qog ntawm qog. Lub hlwb hypothalamus thiab pituitary caj pas tswj testosterone ntau lawm. Cov hypothalamus qhia cov pituitary caj pas ntawm ntau npaum li cas testosterone los tsim, thiab pituitary caj pas kis tau cov lus rau cov kab mob. Cov kev sib txuas lus no tshwm sim los ntawm cov tshuaj thiab cov tshuaj hormones hauv cov hlab ntsha.


Testosterone injections xa testosterone rau hauv cov leeg. Qhov kev kuaj ntawd yog thaum nqus tau cov ntshav mus rau hauv cov ntshav. Lub sij hawm nqes yog nyob ntawm hom tshuaj testosterone. Cov tshuaj feem ntau yog siv nyob rau hauv cov caj pas, glutes lossis deltoid leeg.


Cov hom mob uas siv tshuaj tua kab mob ntau tshaj plaws rau kev sim tshuaj (testosterone replacement therapy) (TRT) muaj xws li testosterone enanthate (TE) thiab testosterone cypionate (TC). Testosterone enanthate thiab testosterone cypionate yog hloov cov ntaub ntawv ntawm testosterone. Tshwj xeeb tshaj yog, ib tug carboxylic acid ester tau raug ntxiv rau 17-beta hydroxyl pawg. Qhov txuas ntawd ua TE thiab TC tsawg dua tus qauv dawb dua T. Vim li ntawd, lawv muaj ib nrab hnub ntxiv thiab tau nqes qeeb ntawm qhov chaw txhaj tshuaj. Ib zaug nyob rau hauv cov hlab ntsha, lub ester raug muab tshem tawm los ua lub cev dawb (active) T. Vim lawv lub neej ntev ntev, ob leeg TE thiab TC muab kev tso tawm ntawm testosterone mus rau hauv cov ntshav mus rau ib mus rau ob asthiv. Vim li ntawd, testosterone los ntawm TE lossis TC tsuas xav tau txhaj txhua lub lim tiam lossis txhua lub lim tiam.


Dosing regimens rau TRT, qhov kev pom zoo noj tshuaj ntawm tus testosterone enanthate los yog testosterone cypionate rau testosterone kho yog 75 mus rau 100 mg txhua lub lis piam los yog 150 mus rau 200 mg txhua lwm lub lim piam.1-5 Lub lim tiam tag los muaj ntau dua vim hais tias ntau zaus cov kev hloov qis hauv cov ntshav siab testosterone . Kwv yees li ntawm 30% ntawm cov txiv neej muaj kev sib tw siv testosterone tsawg. [Li ntawm 65% ntawm cov txiv neej siv testosterone gel.





5. Ceeb toom o f Testosterone nyoos hmoov

Koj yuav tsum tsis tau txais testosterone yog tias koj ua xua rau nws, lossis yog tias koj muaj:

 

prostate cancer;

poj niam txiv neej mob cancer;

mob plawv loj heev;

mob siab;

mob raum loj heev; los yog

yog tias koj cev xeeb tub los yog xeeb tub.

Kom paub tseeb tias testosterone zoo rau koj, qhia koj tus kws kho mob yog tias koj muaj:

ntshav qab zib;

loj hlob prostate;

kab mob hauv lub plawv los sis kab mob ntsws coronary artery;

keeb kwm ntawm lub plawv, mob stroke, lossis ntshav khov;

siab roj cholesterol lossis triglyceride (ib hom roj hauv cov ntshav);

mob khees xaws mis (ntawm cov txiv neej, los yog cov poj niam uas muaj cov tshuaj hypercalcemia);

daim siab lossis mob raum;

yog tias koj tau txaj muag los yog ceev nrooj; los yog

yog tias koj noj cov ntshav thiav (warfarin, Coumadin, Jantoven).

Cov tshuaj no tuaj yeem tsim kev puas tsuaj rau tus me nyuam hauv plab los sis ua kom tsis zoo rau cov yug me nyuam. Tsis txhob siv testosterone yog tias koj cev xeeb tub los yog xeeb tub. Qhia rau koj tus kws kho mob tam sim ntawd yog tias koj cev xeeb tub thaum kho. Siv cov txiaj ntsim ntawm kev xeeb menyuam thaum koj tab tom tau txais cov tshuaj no.


Nws tsis paub tias seb testosterone kis mus rau hauv leej niam mis los yog nws yuav ua mob rau tus menyuam mos. Koj yuav tsum tsis txhob pub mis rau noj thaum siv cov tshuaj no.




 

6. Dab Tsi Ua Tuab Taws Teeb Muas Li Cas?  

Kev nyab xeeb ntawm testosterone kho mob tseem tab tom tshawb nrhiav. Nws muaj ntau yam tshwm sim los ntawm kev phiv tshuaj thiab qee lub sij hawm ntev tau, thiab.

 

Piv txwv, testosterone kho kom tsawg phev suav, yog li Michael A. Werner, tus kws paub hauj lwm hauv andropause, los yog "txiv neej menopause," pom zoo tias cov txiv neej uas muaj siab rau yav tom ntej fertility tsis txhob testosterone kho.

 

Lwm cov kev mob tshwm sim muaj xws li kev muaj feem cuam tshuam ntawm cov teeb meem hauv plawv hauv cov txiv neej laus uas tsis muaj mob, raws li xyoo 2009 txoj kev kawm hauv Tsev Kho Mob hauv Boston. Ib txoj kev tshawb fawb txog xyoo 2017 tau luam tawm hauv JAMA pom tias cov kev kho mob nce siab ntsig txog mob ntsws plawv. Ntxiv thiab, cov Food and Drug Administration (FDA) yuav tsum tau tsim cov ntaub ntawv sau rau hauv cov ntawv hais tias lub xeev cov kev kho mob testosterone tuaj yeem ua rau muaj feem ntau ntawm kev mob plawv thiab cov cwj nrag. FDA pom zoo kom cov neeg mob siv cov tshuaj testosterone yuav tsum nrhiav kev kho sai tam sim ntawd yog tias lawv muaj cov tsos mob no:

 

Mob hauv siab

Ua tsis taus pa lossis ua tsis taus pa

Tsis muaj zog nyob rau hauv ib qho los yog ib sab ntawm lub cev

Slurred hais lus

Cov kev kho kuj tuaj yeem ua rau kom muaj kev pw tsaug zog apnea, txhawb prostate thiab kev loj hlob ntawm lub mis, thiab txawm tias txhawb kev tsim kho mob cancer ntawm prostate, raws li Mayo Clinic.

 

Hu rau koj tus kws kho mob ib zaug yog tias koj muaj:

 

xeev siab lossis ntuav;

hloov hauv daim tawv nqaij xim;

ntxiv lossis tsis tu ncua ntawm qhov chaw mos;

impotence, teeb meem ejaculation, txo cov phev txiv neej, txo cov qes loj;

mob nyhav lossis mob nyhav;

ua tsis taus pa luv (txawm tias muaj kev sib tw me ntsis);

mob hauv siab lossis siab, mob kis mus rau koj lub puab tsaig los yog lub xub pwg;

o Nyob hauv koj cov qij taws lossis taw, hnyav nce zuj zus;

tej cim ntawm cov ntshav khov hauv lub ntsws - mob hauv siab, mob hnoos qis, hawb pob, ua pa ceev, hnoos tau ntshav;

cov cim ntawm cov ntshav khov hauv koj txhais ceg - qhov mob, o, sov so, lossis liab liab hauv ib los yog ob sab ceg;

muaj calcium nyob rau hauv cov ntshav - mob plab, quav tawv, nqhis dej ntau dua los yog tso zis, mob nqaij pob txha lossis tsis muaj zog, mob pob qij txha, tsis meej pem, thiab nkees los yog tsis muaj zog; los yog

teeb meem hauv daim siab - mob plab mob, khaus, tsis qab los noj mov, tsaus zis, quav pleev xim daj, daj ntseg (daj ntawm daim tawv nqaij lossis qhov muag).

Cov poj niam uas tau txais testosterone yuav tsim txiv neej yam ntxwv, uas yuav ua tsis tau yog tias kev kho mob txuas ntxiv. Hu rau koj tus kws kho mob ib zaug yog tias koj pom muaj ib qho ntawm cov cim no ntawm cov tshuaj ntsuam xyuas ntau tshaj:

 

pob txuv;

cov kev hloov hauv kev coj khaub ncaws;

txiv neej-txawv cov plaub hau kev loj hlob (xws li ntawm lub puab tsaig lossis hauv siab);

hov los yog tob tob; los yog

loj dua qub.




 

7. Mloog Testosterone   Raw hmoov Hm rom SZOB

Paub →   Mus ntsib peb lub tsev muag tshuaj online thiab sau rau hauv cov khoom siv ntawm cov tshuaj Testosterone.

Paub →   Txhais qhov chaw ntawm tus me nyuam, qhov ntau ntawm qhov khoom thiab kev them nyiaj.

Paub → Nyob hauv lub sijhawm 30 feeb, koj yuav tau txais kev pom zoo ntawm koj daim ntawv txib.

Nws yuav xa tawm tsis pub dhau 12 teev.




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