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> Tsev > Khoom > Pharmaceutical > API > Cov ntsiab lus

Flibanserin Hydrochloride (147359-76-0)

Flibanserin Hydrochloride (147359-76-0)

Flibanserin Hydrochloride, zoo ib yam li Flibanserin, ib yam tshuaj tshiab uas tsis yog hormonal tshuaj rau cov poj niam uas twb dhau mus dhau los ntawm cov poj niam uas tsis muaj teeb meem (HBV). menopause. Cov tshuaj no kuj tsis yog siv los ntawm cov txiv neej.


1. Dab Tsi Flibanserin Hydrochloride   ?

Flibanserin Hydrochloride yog ib tus neeg txheeb ze hauv lub cev ua haujlwm siv los kho cov tsis muaj kev sib daj sib deev tsis zoo hauv cov poj niam uas tsis tau dhau los ntawm cev ntu. Flibanserin Hydrochloride yog tshuaj noj rau cov poj niam ua ntej menopausal nrog rau kev sib deev tsis muaj teeb meem kev sib deev (HSDD), txoj kev uas nws ua haujlwm zoo ib yam li Flibanserin, kuj muaj kev phiv tshuaj nrog Flibanserin, piv nrog Flibanserin, qhov txawv yog Flibanserin Hydrochloride zoo, pheej yig dua tus nqi.

 

Flibanserin Hydrochloride hmoov

Flibanserin Hydrochloride nyoos hmoov, cov khoom siv ntawm Flibanserin Hydrochloride, ib hom Dawb los yog lub teeb daj los yog lub teeb daj daj, ntau cov tshuaj steroids khoom siv feem ntau yuav purity Flibanserin Hydrochloride hmoov hauv online, ua rau txhua hom kev ua tiav Flibanserin Hydrochloride, lub ncauj lus ntawm cov Flibanserin Hydrochloride nyoos hauv SZOB li hauv qab no:


Lub npe: Flibnaserin Hydrochloride

CAS: 147359-76-0

Molecular Formula: C20H21F3N4O · CIH

Molecular phaus: 344.49

Melt Point: 118 ℃

Cia Temp .: RT

Xim: Dawb los yog tua dawb los yog lub teeb daj crystalline hmoov




 

2. Flibnaserin Hydrochloride Li Cas   Ua haujlwm?

Flibanserin Hydrochloride ua haujlwm rau peb lub hlwb cov tshuaj: dopamine, norepinephrine, thiab serotonin. Cov tshuaj no yog cov neurotransmitters. Lawv yog lub luag haujlwm rau xa cov teeb liab ntawm lub hlwb thiab lwm qhov chaw ntawm lub cev los ntawm qhov kev xav ntawm lub paj hlwb.


Dopamine thiab norepinephrine yog koom nrog kev sib deev siab. Txawm li cas los xij, serotonin contributes rau kev sib deev inhibition thiab tej zaum yuav dampen txiv neej tsav. Nws xav tias yog tias cov tshuaj no tsis tshuav nyiaj npaum li cas - yog tias dopamine thiab norepinephrine qib qis thiab / lossis serotonin qib siab dhau - tus poj niam yuav xav tias tsis muaj kev sib deev.


Flibanserin Hydrochloride ua hauj lwm los ntawm raising theem ntawm dopamine thiab norepinephrine thaum uas txo qis ntawm serotonin. Nyob rau hauv no txoj kev, tshuaj uas pab txhawb kev sib deev muaj siab muaj zog thiab ib qho uas yuav suppress muaj siab yuav poob.


Flibanserin Hydrochloride Daim Ntawv Thov:

Flibansetrin hcl muaj high affinity rau serotonin receptors nyob rau hauv lub hlwb: nws ua raws li tus agonist rau 5-HT1A thiab ib antagonist rau 5-HT2A. Nyob rau hauv vivo, flibanserin sib npaug li 5-HT1A thiab 5-HT2A receptors. Txawm li cas los xij, hauv siab siab hlwb 5-HT (xws li, nyob hauv kev nyuab siab), Flibanserin Hydrochloride tej zaum yuav nyob 5-HT2A receptors hauv feem ntau dua 5-HT (1A) receptors. Tej zaum nws kuj tseem mob rau cov kab mob D4 (dopamine) receptors thiab 5-HT2B thiab 5-HTB2C. Nws cov kev txiav txim rau neurotransmitter receptors yuav ua rau kom txo tau serotonin qib thiab nce hauv dopamine thiab norepinephrine ntau ntau, tag nrho cov uas yuav ua tau ib feem hauv kev ua nqi zog.

 

Siv kev kho mob

Flibanserin Hydrochloride yog siv rau kev sib deev hypoactive ntshaw tsis sib xws ntawm cov poj niam. Cov neeg tau txais kev pabcuam Flibanserin Hydrochloride tau tshaj tawm 0.5 tawm ntawm cov placebo hauv cov sijhawm uas lawv tau "txaus siab rau kev sib deev". Cov nyob rau ntawm flibanserin tau nce ntawm 2.8 txog 4.5 npaug ib lub hlis thaum cov poj niam uas tau txais cov placebo tau qhia ntxiv tias "muaj kev txaus siab rau kev sib deev" ntawm 2.7 mus 3.7 zaus hauv ib lub hlis. lub lis piam ntawm kev kho mob thiab kev kho nyob thoob plaws hauv lub caij kho mob.

 

Cov hauj lwm zoo ntawm Flibanserin Hydrochloride tau ntsuam xyuas nyob rau hauv peb theem 3 qhov kev sim tshuaj. Ib qho ntawm peb qhov kev sim siab tau muaj ob qho kev sib sau ua ke, ib qho rau kev sib deev kev sib deev (SSEs) thiab lwm yam kev sib deev. Txhua qhov ntawm 3 kev sim raug kuj muaj qhov kawg kawg uas ntsuas kev ntxhov siab txog kev sib deev muaj siab. Tag nrho peb qho kev sim tau pom tau hais tias flibanserin ua tau nce hauv pes tsawg tus SSEs thiab txo kev ntxhov siab txog kev sib deev muaj siab. Thawj ob qho kev sim siab siv lub xov tooj hluav taws xob los ntsuas kev plees kev yi, thiab tsis pom muaj nce. Ob txoj kev sim no kuj ntsuas kev plees kev yaum kom siv tus poj niam deev luag poj luag txiv (FSFI) ua ib qho kev txiav txim siab thib ob, thiab kev nce qib tau siv txoj kev ntsuas tom kawg no. Lub FSFI tau siv los ua tus thawj sib tw rau kev sib deev hauv kev sib deev nyob rau hauv peb qhov kev sib tw, thiab rov tshwm sim rau qhov tseem ceeb ntxiv.

 

Puas yog Flibanserin Hydrochloride tiag tiag?

Nws tsis zoo li muaj kev kuaj ntshav rau cov poj niam nyiam kev sib deev; ntau npaum li cas koj xav pw ua ke yog ib qho kev ntsuas me me (piv rau Viagra, uas pauv cov yam ntxwv zoo li lub zog thiab ntev ntawm kev erection, Thorp hais). Tab sis txawm tias cov teebmeem me me los ntawm FDA qhov kev txhais lus, lawv yuav ua kom lub ntiaj teb sib txawv rau tus poj niam txoj cai, hais tias Leah S. Millheiser, MD, clinical pab tus kws kho mob hauv cov poj niam thiab cov poj niam thiab tus thawj coj ntawm Txoj Haujlwm Kev Ntxuam Hluas ntawm Stanford University Lub Tsev Kawm Ntawv ntawm Cov Tshuaj. "Yog kuv hais rau nws tias, 'Kuv tuaj yeem txhim kho koj qhov kev lag luam los ntawm ib mus rau ob qho kev sib deev rau ib lub hlis,' uas yog qhov teebmeem ntawm nws tus kheej hauv nws txoj kev sib raug zoo," nws hais. Qhov no tsis yog txhua lub sijhawm rau txhua tus neeg hauv advisory panels, Thorp hais tias, namely cov txiv neej uas xav txog ib mus rau ob qhov txaus siab ntxiv kev sib deev sib tham ib lub hlis kom zoo nkauj tsis tseem ceeb.




 

3. Yuav Siv Li Flibnaserin Hydrochloride ?

Ua ntej yuav noj cov tshuaj Flibanserin Hydrochloride

Koj yuav tsum tsis txhob haus dej haus cawv thaum noj cov tshuaj Flibanserin Hydrochloride. Nws yuav ua rau koj muaj ntshav siab tsis zoo. Koj yuav tsum tsis txhob siv cov Flibanserin Hydrochloride yog tias koj ua xua los ntawm Flibanserin Hydrochloride, los yog koj muaj:

ntshav siab;

keeb kwm ntawm kev quav dej quav cawv los yog quav yeeb quav tshuaj;

daim siab mob;

keeb kwm ntawm kev nyuaj siab los yog mob hlwb; los yog

yog tias koj haus dej haus cawv tam sim no.

Qee cov tshuaj muaj peev xwm ua rau tsis zoo los yog muaj teeb meem thaum siv nrog Flibanserin Hydrochloride.

 

Koj tus kws kho mob yuav tsum hloov koj txoj kev pab them nqi kho mob yog tias koj siv cov tshuaj nram no:

nefazodone;

ib qho tshuaj tua kab mob - ciprofloxacin, clarithromycin, erythromycin, telithromycin;

tshuaj antifungal - fluconazole, itraconazole, ketoconazole, posaconazole;

tshuaj antiviral tshuaj los kho tus kabmob siab C - boceprevir, telaprevir;

lub plawv lossis ntshav siab - tshuaj noj, tshuaj tua ntsev, verapamil; los yog

HIV lossis AIDS tshuaj - atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir.

 

Kom paub tseeb tias Flibanserin Hydrochloride zoo rau koj, qhia koj tus kws kho mob yog tias koj muaj:

keeb kwm ntawm kev quav dej quav cawv los yog quav yeeb quav tshuaj.


Nws tsis paub tias seb Flibanserin Hydrochloride yuav ua rau tus menyuam hauv plab tsis zoo. Qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub.


Nws tsis paub tias seb Flibanserin Hydrochloride kis tau mus rau hauv leej niam mis los yog nws yuav ua mob rau tus menyuam mos. Koj yuav tsum tsis txhob pub mis rau noj thaum siv cov tshuaj no.


Flibanserin Hydrochloride tsis tau txais kev pom zoo siv los ntawm txhua tus neeg uas muaj hnub nyoog yau tshaj 18 xyoo.

 

Thaum koj noj cov Flibanserin Hydrochloride

thaum koj siv cov Flibanserin Hydrochloride, thov txhob txhob ua tej yam nram qab no:

u Tsis txhob haus dej haus cawv thaum noj cov tshuaj Flibanserin Hydrochloride. Haus dej cawv nrog cov tshuaj no tuaj yeem ua rau muaj kev phom sij los yog tsis zoo rau.

Cov txiv kab ntxwv qaub ntsuab thiab cov txiv kab ntxwv qaub kua txiv yuav ua rau cov pob txha flibanserin nd ua rau tsis muaj kev phom sij. Txhob siv cov khoom noj khoom haus thaum noj Noj Addyi.

u Tsis txhob siv tshuaj ntsuab ntxiv: ginkgo, resveratrol, los yog St. John's wort.

l Flibanserin Hydrochloride yuav ua rau koj xav lossis tsis haum. Tsis txhob tsav tsheb los yog kev siv tshuab rau yam tsawg kawg 6 teev tom qab koj noj cov tshuaj no, thiab txog thaum koj paub tias cov tshuaj no yuav cuam tshuam koj li cas. Kiv taub hau los yog ntshav siab yuav ua rau poob lossis lwm yam kev raug mob.

Tsis txhob ceev ceev los ntawm qhov chaw zaum los yog dag, los yog koj xav tias muaj kiv taub hau. Maj mam nce qeeb thiab khov kho koj tus kheej kom tsis txhob poob.

 

Tom qab koj noj Flibanserin Hydrochloride

Tom qab noj Flibanserin Hydrochloride , nws tseem ceeb heev uas yuav tsum nco ntsoov khaws cia thiab muab pov tseg, tam sim no peb tau kawm.


Khaws cov tshuaj no rau hauv lub khob ntim nws tuaj, kaw nruj nreem, thiab tawm ntawm cov menyuam yaus. Khaws nws ntawm chav kub thiab deb ntawm cov cua kub thiab noo noo (tsis nyob hauv chav dej).


Cov tshuaj noj tsis raug cai yuav tsum muab pov tseg rau hauv kev tshwj xeeb kom ntseeg tau tias tsiaj, menyuam, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob siv cov tshuaj no tso rau hauv chav dej. Xwb, txoj kev zoo tshaj plaws los muab koj cov tshuaj noj yog los ntawm kev siv tshuaj kho mob. Tham nrog koj tus kws muag tshuaj los yog hu rau koj lub chaw pov hwm / txua ub no kom paub txog cov kev pab cuam rov qab hauv koj lub zej zog.


Nws yog ib qho tseem ceeb rau kev noj txhua yam tshuaj kom tsis txhob pom thiab ncav cov menyuam yaus kom ntau lub thawv (xws li cov ntsiav tshuaj rau lub limtiam thiab cov neeg rau qhov muag tshuaj, cream, plhaw, thiab nqaum pa) tsis yog menyuam yaus thiab cov menyuam yaus tuaj yeem qhib tau yooj yim. Txhawm rau tiv thaiv cov me nyuam yaus kom txhob raug mob, nco ntsoov kaw lub hau kev ruaj ntseg thiab muab qhov chaw tso rau hauv qhov chaw nyab xeeb - ib qho uas tawm thiab deb thiab tawm ntawm lawv qhov muag thiab ncav cuag.




Cov tshuaj sib txuam ntawm Flibnaserin Hydrochloride yog dab tsi?


Cov Tshuaj Tiv Thaiv Tsis Taus thiab Lwm Yam Mob Hlwb CYP3A4

Cov tshuaj no tuaj yeem ua rau kom cov concentration ntawm Addyi ua rau muaj kev pheej hmoo siab rau kev phiv tshuaj. Hom kab mob qaub ncaug CYP3A4 muaj xws li tshuaj tiv thaiv kabmob qhov ncauj, cimetidine, fluoxetine, Ginko Biloba, thiab ranitidine.

 

Cov CYP2C19 Muaj Zog Kev Cuam Tshuam

Cov CYP2C19 muaj zog tiv thaiv cov kab mob tseem tuaj yeem ua kom qhov kev xav tau ntawm Addyi. Cov CYP2C19 inhibitors yog cov tshuaj tiv thaiv proton (xws li, Prilosec), cov tshuaj serotonin reuptake (xws li, Prozac), benzodiazepines, thiab antifungals.

 

CYP3A4 Inducers

Flibnaserin Hydrochlorideconcentrations raug txo los ntawm CYP3A4 inducers. Kev siv ADDYI nrog ib qho CYP3A4 inducer tsis pom zoo. Cov CYP3A4 inducers muaj xws li carbamazepine, rifampin, rifapentine, thiab St. John 's Wort.

 

Digoxin

Kev siv sib txig ntawm Flibnaserin Hydrochlorideand digoxin yuav nce digoxin ntau. Digoxin ntau qhov yuav tsum tau saib xyuas thaum nyob ntawm Flibnaserin Hydrochloride.

 

Cawv thiab CYP3A4 Cov Tiv Thaiv

Flibnaserin Hydrochloride yog cov tshuaj tsis haum nrog haus dej cawv, mob me me los sis muaj zog CYP3A4 thiab tsis muaj teeb meem. Kev haus dej cawv ntau dua qhov kev pheej hmoo siab, kev tso dag thiab kev nyuaj siab hauv CNS. Kev siv Cuab Yeej lossis CYP3A4 ua kom tsis muaj zog tuaj yeem ua rau muaj kev kub ntxhov thiab kev sib tw

 

Cov kab mob CYP3A4 ua kom muaj xws li: amprenavir, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, verapamil, thiab txiv kab ntxwv qaub kua txiv

 

Cov tshuaj CYP3A4 muaj zog muaj xws li: ketoconazole, itraconzole, posaconazole, clarithromycin, nefazodone, ritonavir, tus kab mob, nelfinavir, indinavir, boceptrevir, telaprevir, telithromycin, thiab conivaptan

 

Mob puas siab ntsws: ib qho kev puas siab puas ntsws tuaj yeem ua rau muaj 4.5-fold ntxiv nyob hauv Flibnaserin Hydrochloride.




 

4. Txaus siab rau ntawm Flibnaserin Hydrochloride


Pom zoo npaum li cas ntawm Flibnaserin Hydrochloride

Nqa Flibnaserin Hydrochloride raws nraim li qhov qhia.Flibnaserin Hydrochloride los hauv daim ntawv xaj thiab noj ib zaug ib hnub, thaum mus pw, 100 mg noj ib hnub.

Siv Flibnaserin Hydrochloride nkaus xwb thaum mus pw. Kev Siv Fibnaserin Hydrochloride nyob rau ib lub sijhawm uas tsis yog sijhawm mus pw yuav ua rau koj tsis muaj ntshav siab, tsaus muag (tsis nco qab), raug mob, thiab tsaug zog.

 

Yuav ua li cas yog tias kuv tsis nco qab noj ib zaug?

Yog tias koj tsis mus txhaj koob tshuaj Flibnaserin Hydrochloride, hla koj cov tshuaj tsis tuaj. Noj koj cov koob tshuaj tom ntej thaum mus pw tom ntej. Tsis txhob noj cov tshuaj Flibnaserin Hydrochloride tom ntej no sawv ntxov los sis ob zaug ntxiv tom ntej. Yog tias koj noj ntau dhau lawm Flibnaserin Hydrochloride, hu rau koj tus kws kho mob.

 

Yuav ua li cas yog tias kuv tsis dhau?

Yog tias koj noj ntau dhau lawm Flibnaserin Hydrochloride, hu rau koj tus kws kho mob lossis Lub Chaw Tswj Tshuaj Lom (Poison Control Center), lossis nrhiav kev kho mob ceev nrooj tam sim ntawd. hu rau Poison Help line ntawm 1-800-222-1222.

 

Qhia rau koj tus kws kho mob yog tias koj cov tsos mob ntawm HSDD tsis tau zoo dua tom qab koj tau siv cov tshuaj Flibnaserin Hydrochloride rau 8 lub lim tiam.




 

5. Ceeb toom o f Flibnaserin Hydrochloride

Tsis txhob haus dej haus cawv thaum noj cov tshuaj Fluibnaserin Hydrochloride, .Qhov ntawm Flibnaserin Hydrochloride, thiab cawv ua rau muaj kev pheej hmoo hypotension thiab syncope; Yog li ntawd, kev siv dej cawv yog qhov tsis zoo.

 

Mob hypotension thiab syncope yuav ua rau ccur thaum Flibnaserin Hydrochloride, siv nrog cov tshuaj CYP3A4 los sis cov neeg mob uas muaj kabmob tsis zoo; Yog li ntawd, Flibnaserin Hydrochloride, siv nyob rau hauv cov chaw no yog contraindicated.

 

Flibnaserin Hydrochloride tsuas yog muaj los ntawm qhov Kev Ntsuam Xyuas Phibniasin Hydrochloride thiab kev txhim kho lub tswv yim (REMS) Program vim yog muaj kev pheej hmoo siab ntawm ntshav siab thiab tsaus muag (tsis nco qab) nrog haus cawv. Koj tsuas tuaj yeem tau txais Flibnaserin Hydrochloride, los ntawm cov chaw muag tshuaj uas koom rau hauv Flibnaserin Hydrochloride, REMS Program.




 

6. Dab Tsi Ua Tuab Taws Teeb Tej Teeb Miv Fibnaserin Hydrochloride?

 

Nrog rau nws cov kev xav tau, ib qho tshuaj yuav ua rau muaj qee yam tsis zoo. Txawm hais tias tsis tag nrho cov kev mob tshwm sim, tej zaum lawv yuav xav tau kev kho mob.

 

Ntau hom

L Qhov muag plooj plooj

u tsis meej pem

l kiv taub hau, tsaus muag, los sis ua tsis taus pa, tshwj xeeb tshaj yog thaum tuaj tos dheev los ntawm kev pw los yog zaum twj ywm

u tawm hws

l   qaug zog lossis tsis muaj zog

l tsaug kev tsaug zog lossis qaug zog tsis zoo

 

Tsawg dua

u Hnov tas li ntawm txhua tus kheej los yog ib puag ncig

l nov ntawm kev sib tw

 

Tsis tshua muaj

l Bloating

u ua npaws

koj xeev siab

mob hnyav heev

• Mob plab lossis mob plab

l ntuav


Qee cov kev mob tshwm sim uas feem ntau tsis xav tau kev kho mob. Cov kev mob tshwm sim no yuav ploj mus thaum kho thaum koj lub cev nyob rau hauv cov tshuaj. Tsis tas li ntawd, koj tus kws kho mob yuav qhia koj txog kev tiv thaiv los yog txo qee qhov kev mob tshwm sim. Nrog koj tus kws kho mob tham yog tias ib qho kev mob tshwm sim tom qab los yog muaj kev ntxhov siab lossis koj muaj lus nug txog lawv




 

7. Yuav tau Flibnaserin Hydrochloride Nyoos Hmoov f rom SZOB

Yuav ua li cas yuav Pharmaceutical Grade Flibnaserin Hydrochloride hmoov los ntawm SZOB nyaus tuam txhab?

→ Mus xyuas peb lub tsev muag tshuaj online thiab sau cov lus qhia ntawm Flibnaserin Hydrochlorideraw cov ntaub ntawv.

→ Txhais qhov chaw ntawm tus me nyuam, qhov ntau ntawm qhov khoom thiab kev them nyiaj.

Paub → Nyob hauv lub sijhawm 30 feeb, koj yuav tau txais kev pom zoo ntawm koj daim ntawv txib.

→ Nws yuav xa tawm tsis pub dhau 12 teev.



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