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    Shenzhen OK Biotech Technology Co., Ltd. (SZOB)

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> Tsev > Khoom > Pharmaceutical > API > Cov ntsiab lus

Finasteride (98319-26-7)

Finasteride (98319-26-7)

Finasteride yog ib tug dawb crystalline hmoov, yog siv rau kev kho mob ntawm txiv neej cov plaub hau poob, muag nyob rau hauv lub npe nrov Proscar thiab Propecia nrog lwm tus. tiv thaiv kev hloov ntawm testosterone rau dihydrotestosterone (DHT) nyob rau hauv lub cev.ZOB Muab Siab Purity Finasteride Raw Hmoov Thiab Dawb Roj Dawb Thoob Xwb.Qhov Zoo Yog Txiag Guaranteed, Qhov Zoo Yog Peb Nyiam


1. Finasteride nyoos hmoov yog dab tsi?  

Finasteride muag nyob rau hauv lub npe nrov Proscar thiab Propecia nrog lwm tus, tiv thaiv hloov siab ntawm testosterone rau dihydrotestosterone (DHT) nyob rau hauv lub cev. DHT koom tes hauv kev txhim kho benign prostatic hyperplasia (BPH).


Finasteride yog 4-azaandrost-1-ene-17-carboxamide, N- (1,1-dimethylethyl) -3-oxo -, (5a, 17) -. Empirical formula ntawm finasteride yog C23H36N2O2 thiab nws cov nyhuv molecular yog 372.55. Finasteride yog ib tug dawb crystalline hmoov nrog lub teeb meem ntawm qhov ze ntawm 250 ° C. Nws yog dawb do soluble hauv chloroform thiab hauv qaug dej cawv muaj qis, tab sis nws muaj suab thaj nyob hauv dej.


Finasteride (Propecia) yog siv rau kev kho mob ntawm txiv neej cov plaub hau cov plaub hau poob. Finasteride (Proscar) siv los kho cov tsos mob ntawm benign prostatic hyperplasia (BPH) rau cov txiv neej uas muaj prostate enlarged.This tshuaj no yog siv rau cov txiv neej xwb.

 



 

2. Finasteride nyoos hmoov li cas?

Txiv neej cov plaub hau cov plaub hau poob vim tshwm sim los ntawm cov hauv paus plaub hau yog raug rau cov txheej txheem hu ua androgenic miniaturization. Cov hauv paus plaub hau shrink thiab nws thiaj li tsis ua cov plaub hau vim hloov los ntawm qhov testosterone zoo tib yam rau ib daim ntawv ntawm testosterone hu ua DHT. Qee cov txiv neej scalp hauv paus plaub hau ua rau nce theem ntawm DHT los ntawm shrinking thiab ua thinner plaub hau, kom txog thaum tej zaum siv ceev xwmphem plaub hau zoo rau nws. Nws cuam tshuam txog li 70% ntawm cov txiv neej dhau lawv lub neej.


Finasteride yog 5a-reductase inhibitor, uas yog hom II thiab III isoenzymes.Ua inhibiting 5a-reductase, finasteride tiv thaiv kev hloov ntawm testosterone rau dihydrotestosterone (DHT) los ntawm hom II thiab III isoenzymes, uas ua rau txo qis hauv DHM theem ntawm 65-70% thiab hauv prostate DHT theem ntawm 85-90%, qhov uas qhia ntawm hom II isoenzyme predominates.


Tsis zoo li peb tus thawjcuam ntawm peb cov neeg ua haujlwm tsis muaj teebmeem ntawm peb qhov kev rho tawm ntawm 5to-reductase zoo li dutasteride uas yuav txo tau DHT theem hauv tag nrho lub cev los ntawm ntau tshaj 99%, finasteride tsis tag suppress DHT ntau lawm vim hais tias nws tsis muaj teebmeem loj cuam tshuam rau ntawm 5a-reductase yam I isoenzyme, nrog 100-fold tsawg affinity rau kuv raws li piv rau II.


Los thaiv thaiv DHT ntau lawm, finasteride thiaj li ua rau cov neeg ua haujlwm ua rau tawv nqaij. Hauv prostate, inhibition of 5α-reductase txo cov prostate ntim, uas pab BPH thiab thiaj li yuav muaj mob cancer ntawm prostate. Inhibition of 5a-reductase kuj txo epididymal hnyav, thiab txo cov kom muaj zog thiab cov qauv morphology ntawm spermatozoa nyob rau hauv cov epididymis.


Neurosteroids zoo ib yam li 3a-androstanediol thiab allopregnanolone qhib lub GABAA reseptor; vim hais tias finasteride tiv thaiv tsim tawm ntawm cov hlab ntsha paj hlwb, nws yuav ua rau kom txo tau kev ua haujlwm ntawm GABAA (saib cov neurosteroidogenesis inhibitor).


Kev txo ntawm GABAA tus tau txais kev tso cai los ntawm cov neurosteroids tau raug rau hauv kev nyuaj siab, kev ntxhov siab, thiab kev sib deev tsis taus.


Txuas ntxiv rau inhibiting 5α-reductase, finasteride kuj tau raug pom los ntawm kev sib tw rau cov neeg ua haujlwm tsis zoo (5) thiab ua li no tsis zoo li yuav yog qhov tseem ceeb.


Finasteride txo cov prostate ntim ntawm 20 mus rau 30% ntawm cov txiv neej nrog benign prostatic hyperplasia.

 





3. Siv Finasteride nyoos hmoov?


Prostate enlargement

Cov kws kho mob tej zaum kuj siv finasteride rau cov kev kho mob ntawm BPH, ua lub npe hu ua ib tus mob prostate. Finasteride tuaj yeem txhim kho cov tsos mob ntawm BPH xws li zis nyuaj, nce thaum hmo ntuj kom tso zis, hesitation thaum pib tso zis, thiab qis qis dua. Nws muab cov kab mob symptomatic tsawg tshaj li ntawm alpha-1 blockers xws li tamsulosin thiab cov kab mob symptomatic yog qeeb hauv qhov pib (rau 6 lub hlis los yog ntau tshaj ntawm kev kho mob nrog cov tshuaj finasteride yuav tsum tau txiav txim seb kho cov kev kho mob zoo li cas). Symptomatic cov kev pab cuam mas pom nyob rau hauv cov neeg nrog prostate ntim> 40 cm3. Cov kev tshawb fawb ntev rau finasteride tab sis tsis yog alpha-1 inhibitors txo txoj kev pheej hmoo siab mob (-57% ntawm 4 xyoos) thiab qhov kev xav tau rau kev phais (-54% ntawm 4 xyoos). Yog tias cov tshuaj txuas ntxiv lawm, cov kev pab kho mob yuav rov qab li ntawm 6-8 lub hlis.


Tus qauv hau poob

Finasteride qee zaum siv los kho cov plaub hau txawv (androgenetic alopecia) hauv cov txiv neej nkaus xwb. Kev kho mob ua rau cov plaub hau ploj thiab ntxiv txog 30% kev txhim kho hauv cov plaub hau tom qab 6 lub hlis ntawm kev kho mob, nrog cov hauj lwm feem ntau tsuas yog siv tshuaj ntev li ntev raws li txoj kev noj tshuaj, tab sis lub sij hawm plaub hau poob qis qis qis tom qab tshem tawm. Finasteride tseem tau sim rau cov qauv plaub hau poob rau cov poj niam; cov ntsiab lus tau tsis zoo dua li placebo.


Cov plaub hau ntev zuj zus

Finasteride tau pom tias yuav pab tau zoo rau kev kho mob ntawm hirsutism (ntau lub ntsej muag thiab / los yog cev nqaij cov plaub hau) ntawm cov poj niam. Nyob rau hauv kev tshawb ntawm 89 cov poj niam uas muaj hyperandrogenism vim pheej tsis muaj mob adrenarche syndrome, finasteride tau txo 93% ntawm lub ntsej muag hirsutism thiab txo 73% ntawm lub cev hirsutism tom qab 2 xyoo kev kho mob. Lwm cov kev tshawb fawb siv finasteride rau hirsutism kuj pom nws kom meej meej zoo .


Cov poj niam hloov dua siab tshiab

Finasteride qee zaus siv cov tshuaj hormone hloov kho rau cov poj niam hloov mus rau cov poj niam vim nws cov khoom siv tshuaj tua hluav taws, nrog rau cov tshuaj estrogen. Txawm li cas los xij, kev tshawb fawb me ntsis ntawm kev siv finasteride rau lub hom phiaj no tau ua thiab muaj pov thawj txog kev ua tau zoo tsis dhau. Ntxiv mus, ceeb toom tau raug pom zoo thaum sau txog finasteride hloov cov poj niam, vim finasteride yuav muaj kev phiv xws li kev nyuaj siab, kev ntxhov siab, thiab kev tua tus kheej lub tswv yim, cov tsos mob uas tshwj xeeb tshaj yog nyob rau hauv cov pej xeem thiab hloov mus rau lwm tus neeg muaj kev pheej hmoo.

 

Nyeem Tus Neeg Mob Cov Lus Qhia uas muab los ntawm koj tus kws muag tshuaj ua ntej koj pib noj finasteride thiab txhua zaus koj tau txais ib qho ntxiv. Yog tias koj muaj lus nug txog cov ntaub ntawv, nrog koj tus kws kho mob lossis kws muag tshuaj.


Noj cov tshuaj no los ntawm lub qhov ncauj, nrog los sis tsis noj mov, feem ntau ib hnub, los yog raws li koj tus kws kho mob hais.


Yog tias cov ntsiav tshuaj yog crushed los yog tu nrho, nws yuav tsum tsis pub tus poj niam cev tsis tab seeb los yog tus poj niam uas cev xeeb tub (saib tseem ceeb Tshooj).


Siv cov tshuaj no kom tsis tu ncua kom thiaj li tau txais txiaj ntsim los ntawm nws. Nco ntsoov siv nws tib lub sijhawm txhua hnub. Tsis txhob tsum noj cov tshuaj no yam tsis tau txais kev pabcuam koj tus kws kho mob.

Nws yuav siv sij hawm 6-12 lub hlis los mus pom qhov khoom plig.


Qhia rau koj tus kws kho mob yog tias koj tus mob huam mob los yog tsis zoo.




 

4. Tshuaj o Khoom siv hmoov nplej hmoov Finasteride


Tus Kab Mob Qis Qis Qis rau Menign Prostatic Hyperplasia:

5 mg ntawm qhov ncauj ib zaug ib hnub

Comments:

-Dosing yog tib yam hauv kev kho lub cev thiab kev kho mob ua ke.

 

Feem ntau Tus Neeg Loj Daus rau Androgenetic Alopecia:


1 mg ntawm qhov ncauj ib zaug ib hnub

Rau cov kev kho mob ntawm txiv neej cov plaub hau cov plaub hau poob (androgenetic alopecia) nyob rau hauv cov txiv neej nkaus xwb. (Kev nyab xeeb thiab ua tau zoo rau hauv cov txiv neej ntawm 18 txog 41 xyoos nrog qis me ntsis mus rau cov plaub hau poob ntawm vertex thiab anterior mid scalp cheeb tsam):


Comments:

-Thaum ua ntej siv 3 lub hlis lossis ntau tshaj yog tsim nyog ua ntej kev pom zoo. Kev siv txuas ntxiv yog pom zoo kom tshem tawm cov nyiaj pab.

-Tus thim rov qab ntawm kev kho mob ua rau kev hloov ntawm cov nyhuv hauv 12 lub hlis.

Siv: Rau kev kho mob ntawm txiv neej tus qauv plaub hau poob (androgenetic alopecia) nyob rau hauv cov txiv neej xwb. (Kev nyab xeeb thiab ua tau zoo rau hauv cov txiv neej ntawm 18 txog 41 xyoos nrog qis me ntsis mus rau cov plaub hau poob ntawm vertex thiab anterior mid taub hau pob ntseg).




 

5. Ceeb toom o f Finasteride nyoos hmoov

Lwm cov tshuaj yuav cuam tshuam nrog finasteride, nrog rau cov tshuaj thiab cov tshuaj yuav tom khw, cov vitamins, thiab tshuaj ntsuab. Qhia rau txhua tus ntawm koj tus kws kho mob txog txhua yam tshuaj uas koj siv tam sim no thiab txhua yam tshuaj uas koj pib lossis siv tsis siv.


Finasteride ntsiav tshuaj USP yog cov tshuaj tiv thaiv hauv qab no:

• Kev mob siab rau txhua qhov ntawm cov tshuaj no.

• Cev xeeb tub. Finasteride siv yog contraindicated rau cov poj niam thaum lawv los yog tej zaum yuav xeeb tub. Vim tias muaj peev xwm ntawm hom II 5a-reductase inhibitors los tiv thaiv kev sib hloov ntawm testosterone mus rau 5α-dihydrotestosterone (DHT), Finasteride yuav ua rau tsis txawv txav ntawm sab nraud genitalia ntawm ib tug pojniam xeeb tub ntawm tus poj niam cev xeeb tub uas tau txais Finasteride. Yog tias cov tshuaj no siv thaum cev xeeb tub, los sis yog tias cev xeeb tub thaum siv cov tshuaj no, tus poj niam cev xeeb tub yuav tsum tau paub txog qhov yuav muaj teeb meem rau tus pojniam xeeb tub.


[Saib Ceeb Toom thiab Cov Kev Xyuam Xim, Siv Cov Kheej Txheeb Zog thiab Kev Tiv Thaiv thiab Kev Qhia Cov Neeg Mob Cov Lus Qhia Txog Cov Poj Niam, cov koob tshuaj Finasteride uas qis qis thaum lub cev xeeb tub tau ua txawv txav ntawm sab nrauv hauv txiv neej .


Cov poj niam yuav tsum tsis txhob siv cov tshuaj Finasteride USP thaum lawv xeeb tub los yog tej zaum yuav xeeb tub vim yog qhov tsis haum ntawm Finasteride thiab cov kev muaj peev xwm tom qab yuav ua rau tus pojniam xeeb tub. Finasteride ntsiav tshuaj USP muaj coated thiab yuav tiv thaiv kev sib tiv tauj nrog cov khoom sib txuam ua ke thaum muaj kev tuav, yog tias cov ntsiav tshuaj tsis tau tawg los yog raug




Ua ntej pib kho tshuaj nrog Finasteride ntsiav tshuaj USP, yuav tsum saib xyuas rau lwm cov mob lwm yam mob uas ua rau zoo li cov tsos mob. Ntxiv rau, prostate cancer thiab BPH yuav coexist.


Cov neeg mob uas muaj cov qhov tso zis loj thiab / los yog lub cev tsis tshua muaj zog zis yuav tsum ua tib zoo saib xyuas rau cov tshuaj tiv thaiv ob sab. Cov neeg mob no yuav tsis yog neeg sib tw rau Finasteride.


Kev kho nrog Finasteride ntsiav tshuaj USP rau 24 lub lim piam los soj ntsuam cov phev tsis zoo hauv cov txiv neej noj qab haus huv pom zoo tsis muaj kev cuam tshuam zoo rau cov phev concentration, mobility, morphology, los yog pH. Ib tug 0.6 mL (22.1%) muaj pes tsawg tus me me hauv ejaculate ntim nrog txo cov phev tag nrho ib tus ejaculate tau ua ke.


Cov no tsis nyob rau hauv lub cev ntau thiab tau thim rov qab thaum tsis ua haujlwm ntawm kev kho nrog rau nruab nrab lub sij hawm rov qab mus rau lub hauv paus ntawm 84 lub as thiv.




 

6. Dab Tsi Ua Tuab Taws Teeb Meem o o Finasteride nyoos hmoov?

Lub 2010 Cochrane txheeb xyuas tau tias cov kev mob tshwm sim los ntawm finasteride muaj tsawg thaum siv rau BPH. Muab piv rau cov placebo, cov txiv neej uas siv cov tshuaj finasteride, tabsis, muaj kev pheej hmoo rau impotence, erectile kawg, tsis muaj libido, thiab ejaculation tsis meej rau thawj xyoo ntawm kev kho mob.Qhov no xyuas cov nqi ntawm cov teebmeam no ua indistinguishable ntawm cov placebo tom qab 2-4 xyoo thiab cov kev mob tshwm sim feem ntau tau zoo dua lub sij hawm.Lwm tus xyuas 2010 pom tias thaum siv cov plaub hau poob finasteride nce cov nqi ntawm cov teeb meem kev sib deev.Ntawm 2016 rov xyuas dua 5a-reductase inhibitors prostatic hyperplasia pom tias kev sib deev kawg yog 2.5 zaus ntau dua nyob hauv cov neeg siv lawv.


Nyob rau hauv cov txiv neej nrog prostatic hyperplasia siv ob leeg 5α-reductase inhibitor thiab ib tug α1-adrenergic reseptor blocker ua rau muaj kev pheej hmoo ntawm erectile kawg piv rau tus neeg saib xyuas nkaus xwb.


Finasteride (Propecia) tau txais kev pom zoo rau cov txiv neej nrog kev sib txawv txij thaum 1998 nrog lwm cov kev phiv tsis tshua muaj tshwm sim li. Tej zaum muaj kev phiv los sis kev sib deev, tab sis feem ntau ntawm cov kev tshawb fawb pom tias cov kev phiv los ntawm kev sib deev no ntxeev thaum siv yeeb tshuaj yog rho tawm.


Muaj ntau cov ntawv xov xwm tshiab uas qhia raws li cov lus nug ntawm tus neeg mob hais tias qhov kev phom sij ntawm kev sib deev yog qhov tseeb, thiab cov tshuaj kuj yuav ua rau muaj kev nyuaj siab thiab kev xav phem rau cov neeg mob uas muaj teeb meem ntawm kev sib deev. lub ntsiab lus kub ntawm cov kws kho mob thiab lwm cov kws kho mob uas kho cov neeg mob cov plaub hau poob, thiab nws zoo li tsis paub, tsis tau txog, ua li cas thoob plaws qhov teeb meem ntawm kev sib deev ntev kev phiv los yog.


Finasteride yog qhov inhibitor ntawm steroid Type II 5a-reductase, uas ua los ntawm kev txo qis ntawm lub cev lub cev hormone dihydrotestosterone (DHT) uas ua rau kev loj hlob ntawm prostate, thiab yog siv los kho cov tsos mob ntawm benign prostatic hyperplasia (BPH) rau cov txiv neej nrog ib tus mob prostate. Proscar muaj nyob rau hauv daim ntawv generic. Feem tshwm sim ntawm Proscar muaj xws li.


impotence,

tsis nyiam ntawm kev sib deev,

teeb meem muaj orgasm,

txawv txav ejaculation,

o rau hauv koj txhais tes lossis ko taw,

o los yog mob hauv koj lub mis,

kiv taub hau,

tsis muaj zog,

kev tsaus muag,

mob taub hau,

los ntswg los yog

pob liab liab.


Hauv qee leej neeg, Proscar tuaj yeem txo tus nqi ntawm cov phev tawm thaum sib deev. Qhov no ua tsis tau. Proscar kuj tuaj yeem nce cov plaub hau kev loj hlob. Kev sib deev phiv los ntawm Proscar yuav ua mus ntxiv tom qab koj tsis noj nws. Tham nrog koj tus kws kho mob yog tias koj muaj kev txhawj xeeb txog cov kev mob tshwm sim no.


Qhov kev pom zoo ntawm Proscar yog ib lub tshuaj (5 mg) tau noj ib hnub ib zaug. Lwm cov tshuaj yuav cuam tshuam nrog Proscar. Qhia rau koj tus kws kho mob txhua daim ntawv sau tshuaj thiab cov tshuaj yuav tom khw thiab cov tshuaj uas koj siv. Proscar tsis pom zoo siv rau poj niam thiab yuav tsum tsis txhob siv thaum cev xeeb tub. Cov tshuaj no feem ntau tsis siv rau cov poj niam. Yog li, nws tsis zoo siv thaum cev xeeb tub los yog pub mis niam.




 

7. Siv Finasteride   Raw hmoov Hm rom SZOB

→ Mus xyuas peb lub tsev muag tshuaj online thiab sau rau hauv qhov kev txiav txim ntawm Finasteride raw khoom.

→ Txhais qhov chaw ntawm tus me nyuam, qhov ntau ntawm qhov khoom thiab kev them nyiaj.

Paub →   Nyob rau lub sij hawm 30 feeb, koj yuav tau txais kev pom zoo ntawm koj daim ntawv txib.

Paub →   Nws yuav xa tawm tsis pub dhau 12 teev .




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